Allergic Asthma Intramuscular Vaccine

-
Bronchial asthma is a chronic inflammatory disease that affects the bronchial tubes and bronchioles in the lungs. Moreover, this condition is caused by several factors including allergens. Allergens are referred to substances that are commonly present in the external environment. This type of pathogen can cause mild to severe irritation to the airway, which may lead to inflammatory process.

Due to this scenario, several clinical practitioners are developing a treatment scheme to prevent these allergens from causing inflammatory processes in the airway. Furthermore, this study proves to be one of the highly-structure approaches that can be developed.

Based on the publication review from Human Gene Therapy, their specialists have established a clinical research. This research had revealed an innovative intramuscular vaccine that can fight against these allergens.

The study was conducted through a clinical investigation. The experimented vaccine was used to an asthmatic mouse. It was injected intramuscularly. The result shows that the asthmatic mouse had significantly improved its condition from the hypersensitivity reaction to allergen.

Current Case Report for Allergic Bronchial Asthma

Below are the recent reported morbidities of allergic bronchial asthma based on WHO (World Health Organization) health portfolio: 

  1. Allergic bronchial asthma has affected more than 300 million of individuals worldwide.
  2. The cases of asthma were doubled for over 1 year.
  3. Additional 250,000 cases of allergic bronchial asthma were reported in U.S. alone.
  4. 5.4 out of 10 individuals are dying from premature allergic bronchial asthma attack in a day.
  5. Developed countries have more morbidity cases of allergic asthma compare to underdeveloped and developing countries.
  6. Urban areas are at 50% higher risk of suffering from allergic asthma compare to rural areas.
  7. Cases of allergic bronchial asthma to men are doubled compared to women (ratio of 2:1).
  8. Allergic bronchial asthma is common to children ages 4 to 10 years old. 

New Vaccine Mechanism of Action

Currently, the treatment used for allergic asthma is corticosteroids. However, this medication works to relive the signs and symptoms of asthma but it does not cure the health problem. The recent developed intramuscular vaccine for allergic asthma uses the method of desensitization.

It is also known as immunotherapy. It means that a certain allergen is introduced to the body through a form of vaccine. Repeated doses on deactivated allergen to the body can help the immune system to build up resistance against these allergens.

The dosages are given repeatedly to reduce the risk of developing allergic bronchial asthma. However, the issue pertaining to the development of this vaccine has been limited. The mechanism of action of the vaccine may vary from one person to another. Clinical tests were done to different people with allergic asthma.

Each person who received the vaccine had shown different reactions. This issue had led the clinical practitioners to research more on engineering the vaccine using the DNA of the specific allergen. The study had pushed the team to stop using the repetitive approach. Instead, they focused on alternating the DNA structure of the allergen, which causes inflammatory processes to the airway.

However, this scenario was not been applied to human experimentation. According to Bruno Pitard, Director of Biotherapy Innovations, he mentioned the need for further studies, which can help explain the therapeutic effect of the vaccine using the new approach. He also mentioned the need to conduct human experimentation with regards to its testability and effectiveness.

Today, the issue related to DNA restructuring of allergen as applicable for human consumption; is still under the preclinical trial. This new method is being developed until final analysis will be established for future use– By Edterchelle Soriano

Comments

Post a Comment

Popular posts from this blog

Basic Procedure of Nebulization

-
Image
Bronchial asthma is a life-threatening respiratory problem that does not exempt anyone. This condition can affect both men and women, young and old. As a matter of fact, it has been enlisted by the World Health Organization as one of the top leading cause of mortality and morbidity cases across the globe. In line with this, several therapeutic regimens and preventive measures were designed to control the number of cases. Among these favorable treatment procedures is the use of nebulization (a dispenser that turns a liquid into a fine mist). This procedure is also used as a primary treatment for other respiratory problems that involve thick and tenacious sputum. So, what is nebulization and how it is used properly? Learning the Basic Keys of Nebulization Nebulization is classified as a dependent nursing care because it requires a doctor’s order to administer medicine for asthmatic patients. However, nurses can educate the folks of the patient (parents or adults) on...
Read more

Medication Side Effects

-
A substance that has a physiological effect when ingested or otherwise introduced into the body, in particular a medicine with intended results (like for asthma treatment), may cause a number of unwanted side effects. These effects can occur when you start a new asthma medication, decrease or increase the dose of a asthma medication, or when you stop using a asthma medication. A side effect that happens in 1% or more of people taking a specific medication is considered by medical researchers to be caused by that particular medication. Examples of common medicine side effects include nausea, vomiting, fatigue, dizziness, dry mouth, headache, itching, and muscle aches and pains. Some side effects may be severe and require medical attention, while others may be mild and of little concern. Severe or annoying side effects are one of the main reasons why people stop taking their medications. If you are having worrisome side effects, your doctor may want to change your dose, try a di...
Read more

Asthma Medicines

-
Asthma Controller Medicines Asthma controller medicines assists in preventing asthma symptoms when taken daily as prescribed. These preventive asthma medicines include several different types. Each works in it’s special ways, and some are more suitable for certain levels of asthma severity. Check out the more suitable one below:- Inhaled Steroids Inhaled steroids, also known as inhaled corticosteroids or ICS for short, have become the main medicine type in asthma treatment for persistent asthma in children and adults. They are more safe in terms of side effects, effective and make a significant difference in the quality of life for people who have asthma. Asthma Leukotriene Modifiers Asthma Leukotriene modifiers are asthma controller medications that are sometimes used in combination with, or instead of, inhaled steroids for people whose asthma is moderate to severe. They are also called Asthma Leukotriene Antagonists. Asthma Long-Acting Beta Agonists Asthma Long Actin...
Read more